AMPHOTERICIN B SODIUM DEOXYCHOLATE

Brand Name & Strength

Amphotret 50 mg

Reconstitution

Reconstitute vial with 10 ml WFI

Further Dilution

Dilute reconstituted solution with diluent to a concentration 0.1 mg/ml (50 mg vial in 500 ml D5 )

Diluent

D5

Administration & Infusion rate

IV infusion

Administer over 2 – 6 hr ; 4 – 6 hr

Storage & Stability

RT

(<25 oC)

Fridge

(2 – 8 oC)

After Reconstitution

- 7 days

After dilution

- -

Remarks

Solution should be protected from light during administration whenever possible. However, short term exposure (< 24 hr) to light during IV infusion does not appreciably affect potency.

Test dose: 1 mg in 20 ml D5 administered over 20 – 30 min may be preferred. Patient’s temperature, pulse, respiration & BP should be recorded every 30 min for 2-4 hr

Final concentration should not exceed 0.1 mg/ml for peripheral infusion or 0.25 mg/ml for central infusion.

An in-line filter (pore size no less than 1 micron) may be used.

Incompatible with NS flush existing IV line with D5 or use separate line.

Rapid infusion may cause hypotension, hypokalemia, arrhythmia and shock.

Monitor for signs & symptoms of infusion–related reactions (fever, chills, hypotension, GI symptoms, breathing difficulties & headache) [

For patients who experience infusion-related immediate reactions, premedication can be considered. Premedication 30-60 min prior to drug administration: NSAID and/or diphenhydramine OR Paracetamol with diphenhydramine OR hydrocortisone.